Cell model-base Toxicology
Environmental toxicnts and Toxicogenomics
Phytoestrogens and Chemoprevention
학력
(Ph.D.) Sungkyunkwan University, Korea ( 1989 )
약력/경력
2011~ , 2006~2008 : Dean of the School of
Pharmacy, Sungkyunkwan University
2010~2011 : President of The Korean Society of
Environmental Health and Toxicology
1995~ : Associate and Full Professor,
Sungkyunkwan University
학술지 논문
(2022)
Comparison of 3D airway models for the assessment of fibrogenic chemicals.
TOXICOLOGY LETTERS.
356,
1
(2021)
Dendropanoxide, a Triterpenoid from Dendropanax morbifera, Ameliorates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells through Autophagy Inhibition.
NUTRIENTS.
14,
1
(2021)
Effects of tobacco compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically regulated genes in lung carcinogenesis.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES.
84,
24
(2021)
Reprogrammed lung epithelial cells by decrease of miR-451a in extracellular vesicles contribute to aggravation of pulmonary fibrosis.
CELL BIOLOGY AND TOXICOLOGY.
(2021)
Anti-fibrotic effects of brevilin A in hepatic fibrosis via inhibiting the STAT3 signaling pathway.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.
41,
(2021)
Pre-validation of a Calu-3 epithelium cytotoxicity assay for predicting acute inhalation toxicity of chemicals.
TOXICOLOGY IN VITRO.
75,
(2021)
Polarity Difference and the Presence of Phytoestrogen Compounds Affecting Estrogenic Activity of Peperomia pellucida Extracts.
SAINS MALAYSIANA.
50,
2
(2020)
Hepatoprotective Potency of Chrysophanol 8-O-Glucoside from Rheum palmatum L. against Hepatic Fibrosis via Regulation of the STAT3 Signaling Pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
23
(2020)
Isolation and Characterization of Phenylpropanoid and Lignan Compounds from Peperomia pellucida [L.] Kunth with Estrogenic Activities.
MOLECULES.
25,
21
(2020)
(-)-Catechin-7-O-beta-d-Apiofuranoside Inhibits Hepatic Stellate Cell Activation by Suppressing the STAT3 Signaling Pathway.
CELLS.
9,
1
(2019)
(–)-Catechin-7-O-β-d-Apiofuranoside Inhibits Hepatic Stellate Cell Activation by Suppressing the STAT3 Signaling Pathway.
CELLS.
9,
30
(2019)
Akt and Notch pathways mediate polyhexamethylene guanidine phosphate-induced epithelial-mesenchymal transition via ZEB2.
TOXICOLOGY AND APPLIED PHARMACOLOGY.
380,
-
(2019)
Effects of beta-Sitosterol from Corn Silk on TGF-beta 1-Induced Epithelial-Mesenchymal Transition in Lung Alveolar Epithelial Cells.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.
67,
35
(2019)
Akt and Notch pathways mediate polyhexamethylene guanidine phosphate-induced epithelial-mesenchymal transition via ZEB2.
TOXICOLOGY AND APPLIED PHARMACOLOGY.
380,
(2019)
beta-Peltoboykinolic Acid from Astilbe rubra Attenuates TGF-beta 1-Induced Epithelial-to-Mesenchymal Transitions in Lung Alveolar Epithelial Cells.
MOLECULES.
24,
14
(2019)
Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells.
JOURNAL OF TOXICOLOGICAL SCIENCES.
44,
4-6
(2019)
In vitro model for predicting acute inhalation toxicity by using a Calu-3 epithelium cytotoxicity assay.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS.
98,
(2019)
Polyhexamethylene guanidine phosphate-induced upregulation of MUC5AC via activation of the TLR-p38 MAPK and JNK axis.
CHEMICO-BIOLOGICAL INTERACTIONS.
305,
단행본
(2012)
기초약무실습.
신일북스.
공동
(2011)
예방약학.
도서출판 신일북스.
공동
(2011)
약무실습을 위한 제약 실무실습 지침서.
신일상사.
공동
(2011)
약학 실무실습을 위한 병원 실무실습 지침서.
신일상사.
공동
(2011)
약학 실무실습을 위한 의약품행정 실무실습 지침서.
신일상사.
공동
(2011)
약학 실무실습을 위한 지역약국 실무실습 지침서.
신일상사.
공동
(2010)
환경과 건강.
성균관대학교 출판부.
주저자
(2005)
질환별로 본 건강기능식품학.
신일상사.
공동
(2004)
건강기능식품.
(주)헤럴드미디어.
공동
(2004)
예방약학 요점.
신일상사.
공동
(2004)
예방약학 I,II.
신일상사.
공동
(2003)
예방약학요점.
신일상사.
공동
(2003)
예방약학 I, II.
신일상사.
공동
(2001)
위생약학 I.II.
신일상사.
공동
(2001)
위생약학.
도서출판 신일상사.
공동
(2000)
영양과 건강.
성균관대학교 출판부.
공동
(2000)
처방조제와 복약지도.
대한약사회.
공동
(1999)
위생약학.
도서출판 신일상사.
공동
특허/프로그램
향부자 추출물로부터 분리된 세스퀴테르페노이드계 화합물을 함유하는, 갱년기 질환의 예방.
14/517,136.
20171024.
미국
향부자 추출물로부터 분리된 세스퀴테르페노이드계 화합물을 함유하는, 갱년기 질환의 예방 또는 치료용 조성물.
10-2013-0125593.
20150116.
대한민국
분진연속포집장치.
10-0549414-00-00.
20060127.
대한민국
담배연기의 유해성 실험장치(Device for testing harmful of cigarette smoke.
0451001.
20040921.
대한민국
우루소데옥시콜린산을 함유한 환경호르몬 독성의 예방 및 치료제.
0368936.
20030109.
대한민국
Formulations for reducing or eliminating toxicity of environmental hormones containing ursodeoxycholic acid.
WO02/28396A1.
20020411.
미국
용접흄 독성시험장치.
0294069.
20010410.
대한민국
학술회의논문
(2020)
Evaluation of fibrotic responses depending on 3D airway model structure.
The 17th 2020 Annual Meeting of KSAAE.
대한민국
(2020)
Pre-validation of in vitro acute inhalation toxicity test using Calu-3 cell.
The 17th 2020 Annual Meeting of KSAAE.
대한민국
(2019)
Chrysophanol 8-O-glucoside inhibits hepatic stellate cells activation via regulation of the STAT3 signaling pathway.
대한약학회.
대한민국
(2019)
Defining key events of PHMG-p in the adverse outcome pathway framework.
대한약학회.
대한민국
(2019)
Identify the role of exosome purified from bronchoaleolar lavage fluid of mice instilled with polyhexamethylene guanidine phophate in naive macrophages.
대한약학회.
대한민국
(2019)
The adverse outcome pathway (AOP) approach in CMIT/MIT induced lung toxicity.
대한약학회.
대한민국
(2019)
The fibrogenic effects of downregulated EV miR-451a from bronchial epithelial cells injury by PHMG-phophate.
대한약학회.
대한민국
(2019)
The role of miRNA-33b-3p in PHMG-p induced lung toxicity.
대한약학회.
대한민국
(2019)
β-Peltoboykinolic acid from Astilbe rubra inhibits TGF-β1-induced epithelial mesenchymal transition in A549 cells.
대한약학회.
대한민국
(2019)
The Role of miR-6126 Upregulated by Polyhexamethylene Guanidine Phosphate in Lung Fibrosis via Targeting PCDH9..
ICTXV.
미국
(2019)
Expression of miRNA Related to Polyhexamethylene Guanidine Phosphate–Induced Epithelial-Mesenchymal Transition (EMT) in A549..
ICTXV.
미국
(2019)
The role of microRNA in polyhexamethylene guanidine phophate induced pulmonary fibrosis.
SOT.
미국
(2018)
Development of high-throughput system for pulmonary fibrosis-related gene screening.
Environmental and biological aspects in toxicological research.
대한민국
(2018)
Induction of epithelial-mesenchymal transition and fibroblast activation by rural PM: potential role in pulmonary.
Environmental and biological aspects in toxicological research.
대한민국
(2018)
Toxic mechanism of epithelial damage associated with polyhexamethylene guanidine phosphate-induced cell cycle arrest and apoptosis through DNA damage in lung alveolar epitheial cells.
Environmental ad biological aspets in toxicological research.
대한민국
(2018)
Astilbe rubra suppresses TGF-β1-induced epithelial mesenchymal transition via inhibition of smad/snail pathway..
Forum 2018 pharmaceutical health science-Environmental toxicology.
일본
(2018)
The pattern profiling of exosomal miRNAs derived from injured bronchial epithelial cell by PHMG-phosphate.
Forum 2018 pharmaceutical health science-Environmental toxicology.
일본
(2018)
Altred microRNA expression patterns related to polyhexamethyleneguanidine phosphate-induced lung toxicity in human alveola adenocarcinoma (A549) cells.
54th congress of the european societies of toxicology.
벨기에
(2018)
The interaction between the guanidine polymers of disinfectants and cytoplasmic organelles.
54th congress of the european societies of toxicology.
벨기에
(2018)
Polyhxamethyleneguanidine-phosphate induces cell cycle arrest and apoptosis through DNA damage in lung alveolar epithelial cells.
화학물질과 환경안전.
대한민국
